CPAP versus Oxygen in Obstructive Sleep Apnea

CPAP VERSUS OXYGEN 1

CPAPversus Oxygen in Obstructive Sleep Apnea

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Obstructive sleep apnea refers to a chronic disease that affects 24%of middle-aged men and 9% of middle-aged women (Gottlieb et al.,2014). Furthermore, a moderate-to-severe form of the illness afflicts9% of men and 4% of women from similar age groups (Gottlieb et al.,2014). Many studies have revealed that obstructive sleep apnea is arisk factor for stroke, coronary heart disease, high blood pressure,and death. Notably, continuous positive airway pressure (CPAP)reduces the incidence of hypertension (Gottlieb et al., 2014).Nevertheless, the adherence is suboptimal, and the benefits apartfrom the management of conventional risk factors are uncertain. Theresearchers examined the effects of nocturnal supplemental oxygen onthe markers of cardiovascular complications. Such evaluation wasmotivated by the realization that intermittent hypoxemia couldunderlie sequelae of sleep apnea (Gottlieb et al., 2014).Consequently, the authors conducted a randomized trial in whichvarious patients with cardiovascular risk factors were recruited andscreened using the Berlin questionnaire. Home testing was also usedto establish the diagnosis of sleep apnea. Participants with an indexof 15 to 50 events per hour were assigned to receive education onhealthy lifestyles and sleep hygiene (Gottlieb et al., 2014). Also,such patients could be provided with either nocturnal supplementaloxygen or CPAP. Subsequently, cardiovascular risk was assessed after12 weeks to determine the 24-hour mean arterial pressure (Gottlieb etal., 2014).

The results showed that 88% of the patients could be evaluated forblood pressure at designated intervals (Gottlieb et al., 2014). The24-hour mean arterial pressure was higher in the group receivingsupplemental oxygen than in the participants receiving CPAP.Additionally, there were no differences between the persons receivingoxygen and those in the control group. Therefore, the researchersproved that patients with cardiovascular risk factors wouldexperience a considerable reduction in blood pressure when treatedwith CPAP (Gottlieb et al., 2014). On the other hand, supplementaloxygen lacked such effects.

Reference

Gottlieb, D., Punjabi, N., Mehra, R., Patel, S., Quan, S., &ampBabineau, D. et al. (2014). CPAP versus Oxygen in Obstructive SleepApnea. New England Journal Of Medicine, 370(24),2276-2285. doi:10.1056/nejmoa1306766